CYP19A1 and Abnormal sperm morphology: Several recent studies have used metabolomic and proteomic analysis to measure semen metabolites and proteins in teratozoospermia patients [18], with the expectation of identifying biomarkers that can be used for clinical diagnosis, and several differential metabolites or enzyme products have been found to be associated with teratozoospermia: antioxidative defense enzymes (AD) [19], angiotensinogen [20], nuclease activity [21], aromatase [22] and seminal ROS [23].