EGFR and colorectal carcinoma: At present, with the increasing understanding towards the CRC biological and pathological foundation, a series of molecular mechanisms related to Oxaliplatin resistance have been dug out in domestic and foreign studies; for instance, the excessive activation of DNA damage repair system, over-expression of the membrane transporter, autophagy resistance of CRC cells, activation of the metalloprotease family-dependent EGFR, LPCAT2-mediated intracellular lipid droplet accumulation, and super-methylation of CpG island [30–32].