To further explore the molecular mechanism of KIF20A/NUAK1 activation-induced CRC cell resistance, related literature was reviewed, and it was discovered that, NUAK1 inactivation in multiple cancer cells suppressed the H2O2-induced Nrf2 nuclear import, accelerated the imbalance of intracellular redox, and led to tumor cell death [24, 25]. Here, NUAK1 is linked to neoplasm.