It can be figured out based on previous exploration and existing basic research reports, the excessive expression and activation of KIF20A/NUAK1 in CRC cells can suppress the Oxaliplatin-induced intracellular redox imbalance and ferroptosis, and induce cell resistance to chemotherapeutics through the GSK3β/Nrf2 pathway. Here, NUAK1 is linked to colorectal carcinoma.