Molecular pathology became very important for choice of treatment and prognosis of malignant tumors, but for adrenal cancers, tumor programmed death-ligand 1 (PD-L1) expression and MSI-H/MMR-D status were not associated with objective response [30] Adrenocortical carcinoma is a Lynch syndrome-associated cancer. This evidence concerns the gene CD274 and adrenal gland cancer.