Cd concurrently increases the expression of FOXM1 and Cyclin D1 downstream of MAPK44/42, which in turn upregulates the kinase Aurora B, leading to Histone H3 phosphorylation at serine 10 site, and resulting in human uterine leiomyoma cell mitosis (Fig. 7). This evidence concerns the gene AURKB and Uterine leiomyoma.