CCND1 and Uterine leiomyoma: Cd concurrently increases the expression of FOXM1 and Cyclin D1 downstream of MAPK44/42, which in turn upregulates the kinase Aurora B, leading to Histone H3 phosphorylation at serine 10 site, and resulting in human uterine leiomyoma cell mitosis (Fig. 7).