In addition, the association and colocalization of Cyclin D1 and FOXM1 determined by immunoprecipitation and PLA, respectively, further indicated a vital role of a Cyclin D1/FOXM1 complex in MAPK/Aurora B/H3S10ph activation induced by Cd exposure in leiomyoma cell proliferation, and presumably initiated by GPER/EGFR signaling as previously reported (Liu et al. 2019). This evidence concerns the gene GPER1 and leiomyoma.