The expression level of PD-L1 in TCs or ICs was correlated with tumor size in dMMR CRC (P = 0.034 and P = 0.019, respectively), and the expression level of PD-L1 in TCs was related to tumor size and histological classification in pMMR CRC (P = 0.020 and P = 0.025), while the expression level of PD-L1 in ICs was related to the age of patients in pMMR CRC (P = 0.045). Here, CD274 is linked to colorectal carcinoma.