CD4 and colorectal carcinoma: The results showed that there were no types of immune cells affected by CMTM6 expression in dMMR CRC (Supplementary Fig. 5b); however, high expression of CMTM6 induced the infiltration of CD4+ memory resting T cells (P < 0.001), while reduced the proportion of CD8+ T cells (P = 0.031) and regulatory T cells (P = 0.042) in pMMR CRC (Supplementary Fig. 5c).