Fifteen genes (KMO, RPS27A, SPNS2, TUBA1B, BASP1, FBRSL1, AATK, PLK5, LRRC75A, TLCD4, IP6K3, DPY19L2P2, LRRN2, BTLA, and ALOX15) in opposite model significantly differentially expressed in patients with sepsis and ARDS compared to those with sepsis alone. The gene discussed is SPNS2; the disease is Sepsis.