For example, METTL3 expression is elevated in breast cancer tissues and cells and can promote the multiplication of breast cancer cells and inhibit apoptosis by targeting Bcl-2 [37]; METTL3 upregulation promotes the metastasis of colorectal cancer cells through miR-1246/SPRED2/MAPK signaling pathway [38]. The gene discussed is BCL2; the disease is breast carcinoma.