According to the previous reports, miR-1269b expression is raised in cisplatin-resistant non-small cell lung cancer tissues and cell lines, and can enhance cisplatin resistance of cancer cells via modulating PTEN/PI3K/AKT pathway [11]; miR-1269b can down-regulate SVEP1 expression through PI3K/Akt signaling pathway, thus expediting the multiplication and metastasis of hepatocellular carcinoma cells [32]. This evidence concerns the gene PTEN and cancer.