For instance, miR-532 is highly expressed in GC, and it can promote migration and invasion of GC cells by targeting NKD1 [8]; miR-4268 inhibits GC cell multiplication by negatively regulating Rab6B expression and inhibiting AKT/JNK signaling pathway [9]; miR-1269b is reported to be highly expressed in various human tumors (such as hepatocellular carcinoma and non-small cell lung cancer), which is relevant to the multiplication, metastasis and drug resistance of tumor cells [10,11]. The gene discussed is MAPK8; the disease is gastric cancer.