A recent study also unfolded a novel role of RV viroplasmic protein NSP5 in preventing premature apoptosis by suppressing non-canonical Transforming growth factor-β (TGFβ) signaling in the microsatellite stable colon carcinoma cell line HT29 [where canonical TGFβ signaling is nonexistent due to a nonsense mutation in Mothers against decapentaplegic homolog 4 (SMAD4)]. Here, SMAD4 is linked to colon carcinoma.