Lipid droplets (LDs) which are the principal cellular storage sites for sterol esters and triacylglycerols within a monolayer of phospholipid with characteristic protein inserts such as adipose differentiation-related protein (ADRP) and perilipin A, may also shape viral pathogenesis and therefore are at an important cross-section between the host cellular lipid metabolism and viral infection [246,247]. Here, PLIN2 is linked to viral infectious disease.