ATG16L1 and Cowden disease: To further the research on the association of ATG16l1 and CD, our laboratory developed the first rat model carrying a CD risk allele, Atg16l1 T300A (F344-Atg16l1em8Rrrc, referred to hereafter as T300A), as well as a knockout rat model of Atg16l1 (SD-Atg16l1em2Rrrc, hereafter referred to as em2) using CRISPR-Cas 9 (43).