We demonstrated the reproducibility of our results by using RT‐PCR to quantify the expression of two significantly upregulated genes (HOXB6, P = 0.02; HOXB8; P = 0.01) and two significantly downregulated genes (COL1A1, P = 0.04; SPARC, P = 0.03) in an independent set of colon adenocarcinomas (CRC‐​RT‐PCR cohort) composed of 30 KRAS‐wt and 15 KRAS‐mt tumors (Fig. S2A). This evidence concerns the gene COL1A1 and colon adenocarcinoma.