KRAS and malignant colon neoplasm: To resolve whether or not the changes in the stromal gene signature expression were simply due to differences in the fraction of stromal versus cancer cells in KRAS‐mt vs KRAS‐wt tumors, we performed multiplex IF staining on KRAS‐wt (n = 23) and KRAS‐mt (n = 12) MSS colon cancer specimens (Fig. 2D,E).