PNPLA6 and neuropathy: PNPLA6 encodes the neuropathy target esterase, which belongs to aprotein family of nine patatin-like phospholipase domain-containing proteins.The most important functional domain is the EST domain.This domain is needed to transform phosphatidylcholine inglycerophosphocholine which is a precursor of acetylcholine(nervous system neurotransmitter).