ACE2 and infection: Figure S1 shows the mechanism of the binding of S-proteins and host receptor ACE2. Figure S2 shows the interactions between virus proteins and host proteins involved in the IFN pathway. Figure S3 shows the S-protein binding subnetwork. Figure S4 shows the innate immune pathway subnetwork. Figure S5 shows the organism layer. Tables S1 and S2 show the complete node and linkage information of the virus-host network. All infection predictions are shown in Table S3, and PPI predictions are presented in Table S4.