Since some of these autoantibodies were more prevalent in SAD patients with kidney involvement (e.g. dsDNA, Sm), the same analysis was repeated in SAD individuals without infection and cancer (data not shown) and in SAD with normal kidney function (Fig. 4B) confirming the correlation between FLC levels with anti-RNA binding protein autoantibodies, anti-dsDNA autoantibodies, RF and a reduction of the complement fractions C3 and C4. The gene discussed is C4A; the disease is infection.