SCN5A and cancer: In colon cancer cells, NaV1.5 activity promotes cancer cell invasion in vitro, in both 2- and 3-dimensional models, and regulates a network of invasion-promoting genes via modulation of the PKA/ERK/c-JUN/ELK-1/ETS-1 transcriptional pathway (House et al., 2010, 2015; Poisson et al., 2020) (Figure 2).