Although the reduced expression of SCN8A, encoding for NaV1.6, and SCN9A, encoding for NaV1.7, might harbor predictive values in CRCa, we are still missing clear information to assert whether they have a role, either causative or consecutive, in the carcinogenesis or whether their expression dysregulation is only correlative to cancer transformation or progression. The gene discussed is SCN9A; the disease is cancer.