Although different NSCLC cell lines (H23, H460, and Calu-1) express mRNA for several Na+ channel isoforms (Roger et al., 2007), the selective inhibition of NaV1.7 activity (using TTX) or reduction of expression (by using small interfering RNA) reduced H460 cell invasion by up to 50%. This evidence concerns the gene SCN9A and non-small cell lung carcinoma.