SCN4B and thyroid gland carcinoma: Importantly, by using databases such as the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA)-Thyroid Cancer (THCA), the authors found that SCN4B expression was an independent indicator of favorable recurrence-free survival (RFS) in patients with classical PTC, further contributing to the notion of the SCN4B as a metastases-suppressor gene (Gong et al., 2018).