CNDP2 and neoplasm: Indeed, Navα subunits are functionally active in cancer cell lines and primary tumor cells cultured in vitro, as well as in murine tumor xenograft tissue slices in vivo (Fraser et al., 2005; Roger et al., 2003; Hernandez-Plata et al., 2012; Nelson et al., 2015b), and their inhibition, using different drugs and small molecules such as TTX, ranolazine, phenytoin, Cn2 or PF-05089771, inhibits invasion (Nelson et al., 2015a, 2015b; Driffort et al., 2014; Batcioglu et al., 2012; Yildirim et al., 2012; Lopez-Charcas et al., 2018; Roger et al., 2003, 2007; Liu et al., 2019).