In rodent models, significant fasting hyperinsulinemia was presented around 3–4 days of HFD prior to hyperglycemia (Ben-Shlomo et al., 2012; Scherer et al., 2012; Turner et al., 2013; Waise et al., 2015) or insulin resistance (Gupta et al., 2017; Mosser et al., 2015). This evidence concerns the gene INS and hyperinsulinism.