We established a cell-based drug screening system to identify compounds that protect cells from SARS-CoV-2-induced cytopathology (Figure 1A): VeroE6/TMPRSS2 cells were treated with compounds for 1 hr during inoculation with a clinical isolate of SARS-CoV-2 (Matsuyama et al., 2020) at a multiplicity of infection (MOI) of 0.01 (or 0.001 for the indicated assay). Here, TMPRSS2 is linked to infection.