With the aforementioned effects, we investigated the protective effects of PCA in CA-induced rats with stereotaxic administration of elastase in cerebrospinal fluid to histologically imitate human CA, with inhibition of TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms for the suppression of CA formation and SAH at doses of 50 and 100 mg/kg, respectively. The gene discussed is TNF; the disease is cancer.