The expression of GFRA1 mRNA and protein notably reduced with SNHG15 depletion in the two osteosarcoma cells, and miR-381-3p interference abated the inhibitory effect of SNHG15 interference on the mRNA and protein expression of GFRA1 (Figures 8b–d and A1m). The gene discussed is GFRA1; the disease is osteosarcoma.