SNHG15 and osteosarcoma: The luciferase activity was dramatically reduced in miR-381-3p and SNHG15 WT co-transfected groups compared with that in miR-381-3p and SNHG15 MUT co-transfected groups, suggesting that miR-381-3p was a direct target of SNHG15 in osteosarcoma cells (Figure 4b and c).