Additionally, we also discovered that miR-218-5p expression was negatively correlated with circSAMD4A (r = −0.7051, P < 0.0001; Figure 1q) and KLF8 (r = −0.8618, P < 0.0001; Figure 1r), and KLF8 expression was positively correlated with circSAMD4A in osteosarcoma tissues (r = 0.7564, P < 0.0001; Figure 1s). The gene discussed is KLF8; the disease is osteosarcoma.