Similarly, in contrast with the parental osteosarcoma cell lines HOS and U2OS, circSAMD4A (Figure 1d) and KLF8 (Figure 1l and p) were also significantly increased and miR-218-5p (Figure 1h) was decreased in DXR-resistant cell lines HOS/DXR and U2OS/DXR. Here, KLF8 is linked to osteosarcoma.