Derived from homeodomain-interacting protein kinase 3 (HIPK3), circRNA HIPK3 (circHIPK3) (ID: hsa_circ_0021593 in circBase; Position: chr11:33279167-33369559) is a well-studied circRNA in human cancers, playing an oncogenic role in prostate cancer, nasopharyngeal carcinoma (NPC), and glioma [9,10,11], as well as in lung cancer [12]. Here, HIPK3 is linked to central nervous system cancer.