LncRNA TUG1 was downregulated in glioma tissues and cells and inhibited cell proliferation and invasion by targeting miRNA-145 in regulating glioma cell self-renewal [17], sponging miRNA-299 in promoting angiogenesis [18], and interacting with miR-144 in modulating blood–tumor barrier permeability [19]. The gene discussed is TUG1; the disease is glioma.