As shown in Figure 5b and c, LINC00461 knockdown suppressed glioma progression, which was counteracted in the presence of anti-miR-216a or pcDNA-AQP4, as evidenced by rescued cell viability and cloning ability (Figure 5b–d) and improved migration and invasion (Figure 5e and f). This evidence concerns the gene AQP4 and central nervous system cancer.