It has been reported that LINC00461/miRNA-149-5p/LRIG2 existed in hepatocellular carcinoma [9], LINC00461/miRNA-15a/miRNA-16/Bcl-2 happened in multiple myeloma [10], LINC00461/miRNA-30a-5p/integrin β3 occurred in breast cancer [11], and LINC00461/miRNA-411-5p/TOP2A participated in glioma [12]. The gene discussed is TOP2A; the disease is breast cancer.