CCND1 and central nervous system cancer: Later, Yang et al. [8] demonstrated that LINC00461 is important for glioma progression as evidenced by declined cyclinD1/A/E expression, G0/G1 cell cycle arrest, inhibited glioma cell proliferation, migration, and invasion when LINC00461 was downregulated, which was accompanied with inhibition of miRNA-9; meanwhile, MAPK/ERK and PI3K/AKT signaling pathways were inactivated, while cell apoptosis did not alter in U251 and U87MG cells after lentivirus infected with shRNA against LINC00461.