LGR5 and central nervous system cancer: For example, Zhang et al. [20] found that miR-216a was significantly decreased in glioma tissues and cell line including U251MG, U87MG, U118, and A172, and its overexpression could suppress the proliferation, migration, and invasion of glioma cells by targeting Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), which suggests a tumor-suppressive role of miR-216a in glioma.