For instance, myosin VI is regulated by DNA damage in a p53-dependent manner and possesses a promoted effect in the p53-dependent pro-survival pathway in RKO cells [19]; disordered expression of myosin-X could cause poor prognosis in breast cancer [20]; and Myh9 could stimulate the development of squamous cell carcinomas [21]. The gene discussed is TP53; the disease is breast cancer.