Moreover, the levels of lnc-PICSAR, REV3L mRNA and REV3L protein were drastically reduced, and miR-485-5p was drastically increased in tumor tissues from sh-lnc-PICSAR groups compared to sh-NC groups, as analyzed by the qRT-PCR assay, western blot assay and IHC assay (Figure 8d–h). This evidence concerns the gene REV3L and neoplasm.