Next, the potential effects of LINC00202 on RB cell tumorigenesis were investigated; LINC00202 was knocked down in RB cell lines by using small interference RNAs; as expected, si-LINC00202 significantly reduced LINC00202 expression when compared with the si-NC group in Y79 and HXO-RB44 cells (Figure 1b). The gene discussed is FAM238C; the disease is retinoblastoma.