In order to determine whether miR-223-3p regulated NSCLC progression through targeting RHOB, si-RHOB and anti-miR-223-3p were co-transfected into SK-MES-1 and H1299 cells to examine RHOB expression, cell viability, apoptosis, migration, and invasion in NSCLC cells. Here, RHOB is linked to non-small cell lung carcinoma.