Our previous study also found that the expression level ofFXYD6 protein in HCC, thyroid carcinoma, and colon carcinoma was higher than that in thecorresponding normal tissues by conducting a immunohistochemical screen on a commercialhuman tissue array and that FXYD6 protein was expressed in some HCC cell lines and hascontributed to the proliferation and metastasis of HepG2 cells by upregulating theα1 subunit of Na, K-ATPase in vitro and activating the downstream Src-ERKsignaling components [8]. This evidence concerns the gene FXYD6 and thyroid gland carcinoma.