The aim of this study was to investigate the expression of FXYD domain-containingion transport regulator 6 (FXYD6) mRNA and protein in hepatitis B virus(HBV)-related hepatocellular carcinoma (HCC) tissues with cirrhosis, thecorresponding paracancerous tissues and the normal liver tissues, and to explorethe clinical significance of FXYD6 expression in HBV-related HCC withcirrhosis. This evidence concerns the gene FXYD6 and hepatocellular carcinoma.