In this study, we followed up the HCC patients undergoing radical surgery for 1 year andfound that there was a statistically higher recurrence rate in the HCC patients with thepositive expression of FXYD6 protein than that with the negative expression of FXYD6protein (53.7% vs. 18.2%; p = 0.036). The gene discussed is FXYD6; the disease is hepatocellular carcinoma.