FXYD6 negative reactivity was observed in10/15 (66.7%) and 18/28 (64.3%) in normal liver slides and cirrhosis slides,respectively (Table 2).However, the positive expression rate of FXYD6 was 4/7 (57.1%) forwell-differentiated HCC, 20/24 (83.3%) for moderately differentiated HCC, and 17/21(81.0%) for poorly differentiated HCC. Here, FXYD6 is linked to Cirrhosis.