Radical surgery is currently the most effective therapy for HCC, butdue to high recurrence rate, there is no breakthrough in the overall prognosis of HCC.Since FXYD6 could promote HCC cell invasion and proliferation [8], we assumed that increased level of FXYD6protein may contribute to early HCC recurrence through promoting tumor cells MVI which,in turn, facilitates intrahepatic dissemination of the tumor and thus upgrading thepathological stage. Here, FXYD6 is linked to hepatocellular carcinoma.