Before treatment, total serum IgE in 87 PNS children [(6.33 ± 8.27) × 105 IU·L-1) was significantly higher than that in healthy controls [(0.85 ± 0.69) ×105 IU·L-1] (t = 2.51, P<0.05). This evidence concerns the gene IGHE and paraneoplastic neurologic syndrome.