FOXP3 and lipoid nephrosis: Although IL-10 is produced by a variety of cells including monocytes, T cells, B cells and glomerular basement membranes, Araya [17] found that in cell suspension from the co-culture of Foxp3+T cells and effector cells from MCNS patients, lL-10 decreased significantly; suggesting that the inadequate secretion of lL-10 may be mainly due to the insufficient number of Foxp3 + Treg cells, or its reduced function.