Though LBHD1 has a limited effect in human development and human disease itself, LBH, the conserved domain of LBHD1, has been reported to be associated with congenital heart disease [17, 18, 19], rheumatoid arthritis [20], angiogenesis, endochondral bone formation [21], nasopharyngeal carcinoma[22],. Here, LBH is linked to congenital heart disease.