In order to improve the understanding of the disease and reduce misdiagnosis, a retrospective analysis of the cerebrospinal fluid S100 protein and NSE was processed, based on the diagnostic result of the children who had either Kawasaki disease with aseptic meningitis or the purulent meningitis, between January 2014 and December 2015 in our hospital. The gene discussed is ENO2; the disease is meningitis.