ERBB2 and cancer: HER2/c-erbB-2 positive expression in cancer tissue was significant correlated with the pathology grading (p<0.05), tumor invasion depth (p<0.05) and local regional lymph node metastasis (p<0.05); However, HER2/c-erbB-2 expression was not correlated with the patients age, gender, tumor location and tumor diameter (p>0.05), Table 1.