EPHB4 and neoplasm: ,37 Second, although EPHRIN B2-dependent interactions with EPHB4 are associated with cellular proliferation,23,38,39 and the blockade of EPHRIN B2-EPHB4 binding may be a therapeutic target in some tumor cells,40, 41, 42 EPHRIN B2-dependent interactions with EPHB4 do not promote cellular proliferation in RMS cells.24