Although the immunodeficient mouse model is unsuitable for assessing immunological off-tumor/off-target toxicity due to substantial interspecies divergence between rodents and humans, the extracellular EPHB4 receptor region contains a conserved 186-amino acid N-terminal ligand-binding domain (EPHLBD) (Figure S6A), which facilitated the binding of receptors to their ephrin ligands, EPHRIN B2. The gene discussed is EFNB2; the disease is neoplasm.