Accordingly, a SPSD patient with amphiphysin antibodies will be screened for breast cancer or small cell lung cancer; a SPSD patient with GlyR antibodies will be screened for a thymoma, and has an excellent prognosis once this is removed; while the patient with GAD antibodies will be regularly screened for the occurrence of diabetes, autoimmune thyroid disease or pernicious anemia.19 Here, GAD1 is linked to pernicious anemia.