Some reports suggest that estrogen receptor α (ERα) signaling increases IL-17A production in Th17 cells by upregulating IL-23R expression in a Let-7f-dependent manner, and this might be a reason for the increasing prevalence of systemic lupus erythematosus (SLE) and multiple sclerosis in women [90]. Here, ESR1 is linked to systemic lupus erythematosus.