Induction of diabetes in Tg 15-LOX-1 mice caused a significant decrease in intraepidermal nerve fibers compared to that in control Tg 15-LOX-1 mice but the decrease in corneal nerve fiber length in diabetic Tg 15-LOX-1 mice was not significant compared to that in control Tg 15-LOX-1 mice. This evidence concerns the gene OLR1 and diabetes mellitus.