In hypertensive subjects, visfatin provides a link between cancer and obesity via (i) acting as a proinflammatory cytokine linking obesity to cancer [38] and (ii) triggering the proangiogenic, invasive, and metastatic nature of visfatin in obese hypertensive subjects with hyperlipidemic conditions leading to increased estrogen levels and thereby breast cancer [39]. This evidence concerns the gene NAMPT and obesity due to melanocortin 4 receptor deficiency.