The CFU test showed that the Exo-M5-IFITM3 group had a significantly higher spleen bacterial load compared to the Exo-M5-siIFITM3 group at 3, 5, and 7 weeks of infection, but was still lower than that of the PBS control group at 3 and 5 weeks of infection (p < 0.05) (Figure 7B). The gene discussed is IFITM3; the disease is infection.