Also, bacterial and fungal infections induce recruitment of corneal epithelial cells, corneal stromal fibroblasts, and PMN leukocytes in the tear film that upregulate cytokines (IL-1, IL-6, and IL-8), leukocyte infiltration, and angiogenic factors that induce explosive production of MMPs to lead to stromal scarring and loss of corneal transparency (12, 18, 19, 78). The gene discussed is IL6; the disease is fungal infectious disease.