In order to clarify why arthrochalasia and dermatosparaxis EDS display different clinical phenotypes (Van Damme et al., 2016) and to investigate the diverse functions of ADAMTS2 and ADAMTS14 in vivo (Dupont et al., 2018), N-Tails analysis has been performed on skin samples from wild-type mice (Wt) and TS2−/−, TS14−/− and TS2−/−TS14−/−. The gene discussed is ADAMTS2; the disease is Ehlers-Danlos syndrome.