Such receptors are highly expressed in different tissues, mainly in lung pneumocyte type II cells, with SARS-CoV-2 bindings to ACE2 leading to downregulation of protective ACE2 and induction of hyper-inflammation and oxidative stress, with consequent progress of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) (2). The gene discussed is ACE2; the disease is acute lung injury.