SLC7A5 and esophageal squamous cell carcinoma: Wang et al. discovered that plasma circ-SLC7A5 could serve as novel diagnostic biomarker for ESCC detection, with the area under the ROC curve of 0.772, and plasma circ-SLC7A5 expression was significantly up-regulated in ESCC patients, positively related to TNM stage and tend to have a poor overall survival (47).