Moreover, the plasma hsa_circ_0001445 levels in HCC patients were associated with serum AFP levels, and the efficiency of the combination in distinguishing HCC patients from patients of cirrhosis (AUC = 0.743), from patients of HBV (AUC = 0.877), or from healthy controls (AUC = 0.970) was higher compared to using plasma hsa_circ_0001445 levels or serum AFP levels alone. The gene discussed is AFP; the disease is Cirrhosis.