AFP and hepatocellular carcinoma: Furthermore, Zhang et al. (89) identified that hsa_circ_104075 was highly expression in HCC serum, and the AUC value of hsa_circ_104075 (0.973) was higher than that of lncRNA (DANCR: 0.851, HULC: 0.855, UCA1: 0.735), miRNA (miR-223: 0.818, miR-21: 0.782) and classical protein biomarkers (AFP: 0.750, AFP-L3: 0.766, DCP: 0.771), with a sensitivity of 96.0% and a specificity of 98.3%.