KLF6 and liver cancer: Recently, one study showed that the expression of KLF6-SV1 is up-regulated not only in the carcinogenic Ras/PI3K/Akt-dependent signal pathway (Yea et al., 2008), but also in the carcinogenic HGF/PI3K/Akt-dependent signal pathway (Munoz et al., 2012), thereby changing the relative ratio of KLF6 Full to KLF6-SV1, which in turn leads to increased proliferation of liver cancer cells (Figure 3).