KLF6 and lung carcinoma: At the same time, KLF6-SV1 overexpression has also been shown to significantly promote the survival of lung cancer cell lines, which may be related to the increased expression of the pro-antiapoptotic gene Bcl-2 and the inhibition of the expression of the pro-apoptotic gene Noxa (DiFeo et al., 2008; Figure 4A).