KLF6 and squamous cell carcinoma: Moreover, in a clinical comparative study of 79 patients with non-small cell lung carcinoma (NSCLC), researchers found that KLF6-SV1 expression levels in lung adenocarcinoma were dramatically higher than those in squamous cell carcinoma, and the high expression of KLF6-SV1 was closely associated with lymph node metastasis, tumor stage, and poor prognosis of NSCLC patients, so they postulated that KLF6-SV1 could be used as a new prognostic biomarker after surgery (Zhang et al., 2018).