KLF6 and lung adenocarcinoma: In lung adenocarcinoma cells, the up-regulation of KLF6-SV1 can reduce the sensitivity of patients to cisplatin chemotherapy, while the down-regulation of KLF6-SV1 mediated by siRNA can restore the sensitivity of lung adenocarcinoma cells to chemotherapy (DiFeo et al., 2008; Sangodkar et al., 2009).