To identify mechanisms of SPTBN1 in osteoporosis, we explored pathways related to SPTBN1 by STRING website and found that SPTBN1 may associate with TGF-β/Smad3 and STAT1/Cxcl9 signaling pathways (Supplementary Figures 1A,B). This evidence concerns the gene SPTBN1 and osteoporosis.