Mechanically, miR-29c-3p would promote CS through both p53/p21 and p16/pRB pathways, targeting CNOT6, the subunit 6 of the CCR4–NOT transcription complex, which prevents cell death and senescence (Mittal et al., 2011; Shang et al., 2016). Here, TP53 is linked to Cowden syndrome 1.