Among the potential candidates (Supplementary Table 1), MCL1 (Figure 4A), a protein belonging to the Bcl-2 family that plays critical anti-apoptotic roles, attracted our attention since it confers MDR in acute myeloid leukemia (Hermanson et al., 2013) and is also positively related to drug resistance in several types of cancer (Campbell et al., 2010; Sugio et al., 2014; Ou et al., 2015; Badejo et al., 2016). The gene discussed is BCL2; the disease is cancer.