In the HER2 positive subtype of breast cancer it was reported that the capture of MTs at the leading edge of migrating cells was enhanced by the activation of the receptor HER2 by its ligand heregulin (HRG) via the formation of a complex that also includes Memo, RhoA and mDia1 (Zaoui et al., 2008, 2010). The gene discussed is ERBB2; the disease is breast cancer.