However, the compartmentalization of FN1 into EVs is emerging as a novel and consistent feature of several cell types including HSC, melanocytes, trophoblasts, or cancer cells but with few exceptions mechanistic and functional studies are lacking (Antonyak et al., 2011; Atay et al., 2011; Peinado et al., 2012; Sung et al., 2015; Bin et al., 2016; Purushothaman et al., 2016; Li et al., 2020). Here, FN1 is linked to cancer.