Under conditions of metabolic stress, lipid accumulation in NOS2-/- rat maybe develop into a variety of metabolic syndrome, such as insulin resistance (Jiang et al., 2011), type 2 diabetes (Kopelman, 2000), vascular pathology (O’Rourke et al., 2011) and hepatic steatosis (Festi et al., 2004). This evidence concerns the gene NOS2 and type 2 diabetes mellitus.