SARM therapy as an adjuvant to androgen deprivation therapy in prostate cancer may protect against the adverse musculoskeletal, metabolic and neuro-cognitive impacts of hypogonadism induced by GnRH agonists and other therapies for prostate cancer, while at the same time inhibiting prostate cancer tissue proliferation and growth (Chisamore et al., 2016). The gene discussed is GNRH1; the disease is Familial prostate cancer.