In acromegaly (a condition with elevated GH and IGF-1 concentrations due to a pituitary tumour) (Dineen et al., 2017) some but not all studies have suggested an increased risk of developing cancer (Sherlock et al., 2010; Dal et al., 2018; Dworakowska and Grossman, 2019). The gene discussed is IGF1; the disease is cancer.