To our knowledge, the most studied and understood mitophagy pathway is mediated by PTEN-induced kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin (Narendra et al., 2008; Vives-Bauza et al., 2010), both of which have been linked to forms of Parkinson’s disease (Kitada et al., 1998; Valente et al., 2004). This evidence concerns the gene PINK1 and Parkinson disease.