WB results showed that ATF3 expression was significantly downregulated in ccRCC tissues compared with that in adjacent normal tissues (Figures 1G,H), and RT-PCR assays also confirmed that there was a significant decrease in ATF3 mRNA levels in 16 of the 24 pairs of tissues (Figure 1I). This evidence concerns the gene ATF3 and nonpapillary renal cell carcinoma.